Samartsev Viktor Nikolaevich

  

 

WORK ADDRESS
Mari State University
424000, Yoshkar-Ola, 1 Lenin Square
Phone: +7 (8362) 68-79-30
E-mail: samvic56@mail.ru

ACADEMIC QUALIFICATIONS
Doctor of Biological Sciences, Professor
Gorky Medical Institute (1978-1984).
Doctoral studies at the Faculty of Biology, Lomonosov Moscow State University (1995-1999).
Academic degree: Doctor of Biological Sciences (Diploma No. 002323); specialty 03.00.04 Biochemistry; the topic “Participation of anionic carriers of the inner mitochondrial membrane in the uncoupling action of fatty acids”; defended on November 18, 1999 at A.N. Bach Institute of Biochemistry of RAS; the award of the Higher Attestation Commission of the Russian Federation on March 3, 2000.
Academic title: Professor at the Department of Biochemistry and Molecular Biology (Order No. 001269); awarded on December 23, 2006 No. 2704/475-p.

POSITIONS HELD
Professor at the Department of Biochemistry and Physiology, Head of the Laboratory of Molecular Bioenergy, Mari State University

RESEARCH INTERESTS
Biophysics;
Bioenergy;
Biochemistry;
Current Problems in Biology;
Psychopathology.

ACADEMIC AWARDS AND GRANTS
1. Two grants from the Russian Foundation for Basic Research (RFBR):
1.1. No. 01-04-48317 Comparative studies of the uncoupling of oxidative phosphorylation by fatty acids in the mitochondria of various animals, characterized by the effectiveness of thermoregulation;
1.2. No. 05-04-48688 Features of the uncoupling of oxidative phosphorylation in the mitochondria of vertebrates under the influence of stress factors and aging.
2. Three research programs “Universities of Russia”:
2.1. UR.07.01.049 Comparative study of the mechanisms of uncoupling of oxidative phosphorylation by fatty acids in mitochondria of poikilothermic and homeothermic animals with different body weights;
2.2. UR.07.01.013 Comparative study of fatty acid uncoupling of oxidative phosphorylation in mitochondria of homeothermic animals of different ages;
2.3. UR.07.01.110 Comparative study of the uncoupling effect of fatty acids in the mitochondria of animals with a maximum lifespan during aging and oxidative stress.
3. The project of the analytical departmental target program “Development of the scientific potential of higher education (2009-2011)” No. 2.1.1/4556 (2.1.1/13090) Study of mechanisms and ways of regulating the action of free fatty acids as inducers of the permeability of the outer mitochondrial membrane for proteins.

TRAINING OF HIGHLY QUALIFIED PERSONNEL
Three candidates of Sciences

MEMBERSHIP IN EDITORIAL BOARDS OF JOURNALS
Member of the Editorial Board of the journal “University proceedings. Volga region. Natural sciences”

TOTAL NUMBER OF PUBLICATIONS
Over 200 

MAIN PUBLICATIONS
1. Samartsev V.N., Zeldi I.P. The role of SH-groups in malate regulation of oxidative phosphorylation and palmitate-uncoupled respiration in rat liver mitochondria. Biochemistry. 1995. Vol. 60. P. 635-643.
2. Bodrova M.E., Markova O.V., Mokhova E.N., Samartsev V.N. The role of ADP/ATP antiporter in the uncoupling action of fatty acids in liver mitochondria. Biochemistry. 1995. Vol. 60. P. 1349-1357.
3. Samartsev V.N., Smirnov A.V., Zeldi I.P., Markova O.V., Mokhova E.N., Skulachev V.P. Involved of aspartate/glutamate antiporter in fatty acid-induced uncoupling of liver mitochondria. Biochim. Biophys. Acta. 1997. V. 1339. P. 251-257.
4. Samartsev V.N., Mokhova E.N., Skulachev V.P. The pH-dependent reciprocal changes in contribution of ADP/ATP antiporter and aspartate/glutamate antiporter to the fatty acid-induced uncoupling. FEBS Lett. 1997. V. 412. P. 179- 182.
5. Samartsev V.N., Mokhova E.N. Effect of cysteinesulfinate on fatty acid-dependent uncoupling: modulation of recoupling by the substrates of aspartate-glutamate antiporter and diethyl pyrocarbonate. Biochemistry. 1997. Vol. 62. P. 581-587.
6. Samartsev V.N., and Mokhova E.N. ADP/ATP antiporter- and aspartate/glutamate antiporter-mediated fatty acid-induced uncoupling of liver mitochondria. Biochem. Mol. Biol. Int. 1997. V. 42. P. 29-34.
7. Samartsev V.N., Zeldi I.P., Mokhova E.N. Involvement of aspartate/glutamate antiporter in uncoupling effect of fatty acids in heartmitochondria. Biochemistry. 1998. Vol. 63. P. 678-683.
8. Markova O.V., Bondarenko D.I., Samartsev V.N. Anion carriers-mediated uncoupling effect of dicarboxylic fatty acids in liver mitochondria depends on the position of the second carboxyl group. Biochemistry. 1999. Vol. 64. P. 679-685.
9. Samartsev V.N., Markova O.V., Zeldi I.P., Smirnov A.V. Involvement of ADP/ATP antiporter and aspartate/glutamate antiporter in uncoupling effect of fatty acids, lauryl sulfate and 2,4-dinitrophenol in liver mitochondria. Biochemistry. 1999. Vol. 64. P. 1073-1084.
10. Samartsev V.N. Fatty acids as uncouplers of oxidative phosphorylation. Biochemistry. 2000. Vol. 65. P. 1173-1189.
11. Samartsev V.N., Simonyan R.A., Markova O.V., Mokhova E.N., and Skulachev V.P. Comparative study on uncoupling effects of laurate and lauryl sulfate on rat liver and skeletal muscle mitochondria. Biochim. Biophys. Acta. 2000. V. 1459. P. 179-190.
12. Bodrova M.E., Dedukhova V.I., Samartsev V.N., and Mokhova E.N. Role of ADP/ATP-Antiporter in Fatty Acid-Induced Uncoupling of Ca2+-Loaded Rat Liver Mitochondria. IUBMB Life. 2000. V. 50. P. 189-194.
13. Samartsev V.N., Markova O.V., Chezganova S.A., Mokhova E.N. Changes in the degree of involvement of ADP/ATP antiporter and aspartate/glutamate antiporter in uncoupling effect of fatty acids in liver mitochondria under the influence of the cationic detergent cetyltrimethylammonium bromide. Biochemistry. 2001. Vol. 66. P. 1137-1143.
14. Samartsev V.N., Polishchuk L.S. The proton futile cycle at different energetic conditions of mitochondria. The linear model. Biological Membranes. 2002. Vol. 19. No. 4. P. 303-308.
15. Samartsev V.N., Belosludtsev K.N., Chezganova S.A., Zeldi I.P. Effect of ethanol on uncoupling of oxidative phosphorylation by palmitic acid in liver mitochondria. Biochemistry. 2002. Vol. 67. P. 1502-1510.
16. Khvatova E.M., Samartsev V.N., Zagoskin P.P., Prudchenko I.A., Mikhaleva I.I. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides. 2003. V. 24. P. 307-311.
17. Samartsev V.N., Polishchuk L.S., Paidyganov A.P. Thermodynamic characterization of free oxidation pathways in liver mitochondria. Biophysics. 2003. Vol. 48. No.1. P. 49-53.
18. Samartsev V.N., Chezganova S.A., Polishchuk L.S., Paidyganov A.P., Vidyakina O.V., Zeldi I.P. Temperature dependence of rat liver mitochondria respiration by fatty acids uncoupling of oxidative phosphorylation. Influence of inorganic phosphate. Biochemistry. 2003. Vol. 68. P. 759-768.
19. Samartsev V.N., Paidyganov A.P., Polishchuk L.S., Zeldi I.P. Study on fatty acid uncoupling action in liver mitochondria by different pH of incubation medium. Biological Membranes. 2004. Vol. 21. No. 1. P. 39-45.
20. Samartsev V.N., Polishchuk L.S., Paidyganov A.P., Zeldi I.P. Special features of fatty acid uncoupling action on liver mitochondria of mammalians with different body mass. Biochemistry. 2004. Vol. 69. P. 832-842.
21. Samartsev V.N., Kozhina O.V., Polishchuk L.S. Features of fatty acid uncoupling action on liver mitochondria from rats of different age. Biological Membranes. 2005. Vol. 22. No. 2. P. 92-97.
22. Samartsev V.N., Kozhina O.V., Polishchuk L.S. Relationship between respiration and ATP synthesis in mitochondria at different extents of uncoupling. Biophysics. 2005. Vol. 50, No. 4. P. 660-667.
23. Kozhina O.V., Karatetskova M.P., Samartsev V.N. Recoupling action of ADP during the palmitate-induced uncoupling of oxidative phosphorylation in liver mitochondria. Biological Membranes. 2006. Vol. 23. No. 3. P. 213-218.
24. Samartsev V.N., Kozhina O.V., Polishchuk L.S. Quantitative characteristic of the uncoupling complex formed by ADP/ATP- and aspartat/glutamate antiporters during fatty acid-induced uncoupling in liver mitochondria. Biological Membranes. 2006. Vol. 23. No. 5. P. 402-411.
25. Samartsev V.N., Kozhina O.V., Polishchuk L.S. Comparative study of protonophore and calcium-dependent uncoupling action of palmitate in liver mitochondria of mature and senile guinea pigs Cavia porcellus. Journal of Evolutionary Biochemistry and Physiology. 2006. Vol. 42. No. 4. P. 397-398.
26. Kozhina O.V., Stepanova L.A., Samartsev V.N. Peculiarities of the uncoupling action of fatty acids in liver mitochondria under oxidative stress. Biological Membranes. 2007. Vol. 24. No. 5. P. 421-429.
27. Samartsev V.N., Kozhina O.V., Rybakova S.R. Cyclosporin A inhibits protonophore uncoupling activity of laurate in liver mitochondria. Biological Membranes. 2008. Vol. 25. No. 3. P. 191-195.
28. Samartsev V.N., Kozhina O.V. Oxidative stress as a factor of regulation of fatty acid-induced uncoupling with participation of ADP ATP- and aspartate/glutamate antiporters in liver mitochondria of old rats. Biochemistry. 2008. Vol. 73. No. 7. P. 972-980.
29. Kozhina O.V., Samartsev V.N. Uncoupling activity of fatty acids in liver mitochondria in the presence of substrates ADP/ATP- and aspartate/glutamate antiporters is increased under oxidative stress. Biological Membranes. 2010. Vol. 27. No. 2. P. 184-188.
30. Samartsev V.N., Kozhina O.V. Acetoacetate as the regulator for palmitic acid-induced uncoupling involving liver mitochondrial ADP/ATP antiporter and aspartate/glutamate antiporter. Biochemistry. 2010. Vol. 75. No. 5. P. 698-706.
31. Samartsev V.N., Kozhina O.V., Rybakova S.R. Dependence of uncoupling activity of palmitate in liver mitochondria on body mass of rats of different age. Journal of Evolutionary Biochemistry and Physiology. 2010. Vol. 46. No. 2. P. 164-166.
32. Samartsev V.N., Marchik E.I., Shamagulova L.V. Free fatty acids as inducers and regulators of uncoupling of oxidative phosphorylation in liver mitochondria with the participation of ADP/ATP- and aspartate/glutamate antiporters. Biochemistry. 2011. Vol. 76 .No. 2 .P. 264-273.
33. Samartsev V.N., Kozhina O.V., Marchik E.I., Shamagulova L.V. Involvement of the phosphate carrier as part of the complex with ADP/ATP- and aspartate/glutamate antiporters in palmitic acid-induced uncoupling in liver mitochondria. Biological Membranes. 2011. Vol. 28. No. 3. P. 206-214.
34. Samartsev V.N., Kozhina O.V., Marchik E.I. Simulation of the uncoupling activity of fatty acids with the participation of ADP/ATP- and aspartate/glutamate antiporters in liver mitochondria. Biophysics. 2012. Vol. 57. No. 2. P. 267-273.

 

 

Дата создания: 18.12.2020 14:24
Дата обновления: 18.12.2020 14:24